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| Product: |
NTENSE-2 Capsules - 120 / 700mg |
| Code: |
RAINTE2120 |
| Price: |
$53.44 |
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IN STOCK
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| Description: |
NTENSE-2 CAPSULES
120 capsules (700 mg each)
A combination of 8 rainforest plants which have been independently documented around the world with active pharmacological actions.
For more information on the individual ingredients in NTENSE-2, follow the links provided below to the plant database files in the Tropical Plant Database.
Each rainforest botanical in this proprietary formula has been sustainably harvested in the Amazon Rainforest. Click here to learn more about our rainforest ingredients and wild harvesting methods. This product contains no binders, fillers, or exipients and is 100% finely milled natural plants.
Bringing you the best remedies from
the legends of the Shaman
In2Herbs
Ingredients: A proprietary blend of mullaca, anamu, vassourinha, simarouba, picao preto, suma, cat's claw, and espinheira santa. This formula is 100% pure natural ground plants. No binders, fillers or other additives are used. These plants have been sustainably wild-harvested (grown without pesticides or fertilizers) in the Amazon rainforest and are non-irradiated and non-fumigated.
Suggested Use: Take 3-4 capsules three times daily, or as directed by a healthcare professional.
Contraindications:
* Not to be used during pregnancy or while breast-feeding.
* Several plants in this formula have demonstrated immunostimulant effects therefore this formula is contraindicated before or following any organ or bone marrow transplant or skin graft.
Drug Interactions: None reported.
Documented Research on the
Ingredients of N-TENSE 2
Mullaca
Mullaca has been the subject of recent clinical research which is still ongoing based upon the preliminary studies showing that it is an effective immune stimulant, is cytotoxic to numerous types of cancer and leukemic cells and that it has antiviral properties, including against HIV. Chiang, et.al demonstrated that two chemicals in Mullaca inhibited the growth of several human leukemia cells: K562 (erythroleukemia), APM1840 (acute T lymphoid leukemia), HL-60 (acute promyelocytic leukemia), KG-1 (acute myeloid leukemia), CTV1 (acute monocytic leukemia) and B cell (acute B lymphoid leukemia). In several in vivo animal tests and in vitro lab tests, an extract of the entire plant of Mullaca and/or its steroidal fractions demonstrated immune stimulant properties by strongly enhancing blastogenesis, antibody responses and increased T and B lymphocyte production. Various water, alcohol and ethanol extracts of Mullaca and its plant steroids have shown strong in vitro and in vivo (mice) cytotoxic activity against numerous types of cancer cells including; leukemia, lung, colon, cervix and melanomas. Other research groups in Japan have been focusing on Mullaca's antiviral actions and preliminary studies show that it is active in vitro against Polio Virus I, as well as HIV I; demonstrating reverse transcriptase inhibitory effects. In addition to these actions, Mullaca has demonstrated good antibacterial properties in vitro against numerous types of bacteria.
Chiang, H., 1992 Inhibitory Effects of Physalin B and Physalin F on Various Human Leukemia Cells in Vitro. Anticancer Res 12 4: 1155-1162 (1992)
Lin, Y. S. 1992. Immunomodulatory Activity of Various Fractions Derived from Physalis angulata L Extract. Amer J Chinese Med 20 3/4: 233-243 (1992)
Chiang, H., Antitumor Agent, Physalin F from Physalis Angulata L. Anticancer Res 12 3: 837-843 (1992)
Lee WC, Induction of heat-shock response and alterations of protein phosphorylation by a novel topoisomerase II inhibitor, withangulatin A, in 9L rat brain tumor cells. J Cell Physiol. 1991 Oct;149(1):66-76.
Juang JK, A new compound, with angulatin A, promotes type II DNA topoisomerase-mediated DNA damage. Biochem Biophys Res Commun. 1989 Mar 31;159(3):1128-34.
Pietro RC, et.al., In vitro antimycobacterial activities of Physalis angulata L. Phytomedicine. 2000 Jul;7(4):335-8.
Antoun MD, et.al., Potential antitumor agents. XVII. physalin B and 25,26-epidihydrophysalin C from Witheringia coccoloboides. J Nat Prod. 1981 Sep-Oct;44(5):579-85.
Kusumoto, I., Inhibitory Effect of Indonesian Plant Extracts on Reverse Transcriptase of an RNA Tumour Virus (I). Phytother Res 6 5: 241-244 (1992)
Biological Assay of Antitumor Agents from Natural Products. Anon: Sabstr Seminar on the Development of Drugs from Medicinal Plants Organized by the Department of Medical Science Department at Thai Farmer Bank, Bangkok Thailand 1982 :129-.
Shingu, K., et.al., 1992. Physagulin C, a New Withanolide from Physalis angulata L. Chem Pharm Bull 39 6:1591-1593
Shingu, K., et.al., 1992. Three New Withanolides, Physagulins A, B and D from Physalis angulata L. Chem Pharm Bull 40 8: 2088-2091
Shingu, K., et.al., 1992. Three New Withanolides, Physagulins E, F and G from Physalis angulata L. Chem Pharm Bull 40 9: 2448-2451
Basey, K., et.al., 1992 Phygrine, an Alkaloid from Physalis Species. Phytochemistry 31 12: 4173-4176
Otake,T., et.al., 1995., Screening of Indonesian Plant Extracts for Anti-Human Immunodeficiency Virus- Type 1 (HIV-1) Activity. Phytother Res 9 1: 6-10
Simaruba
In 1962, researchers found that the seeds of Simaruba showed active antiamebic activities in humans and the National Cancer Institute verified that Simaruba seed was 91.8% effective against intestinal amoebiasis in humans in a 1976 study. In much of the early studies, the plant constituents found in the bark, root and leaves of Simaruba attributed with the anti-malarial and antiamebic properties were a group of quassinoids, similar to those found in Quinine Bark. In 1978, scientists discovered a new quassinoid in Simaruba called dehydroglaucarubinone which significantly inhibited the growth of lymphocytic leukemia in vitro. This quassinoid as well as several others found in Simaruba and other plants in the family demonstrated effective antileukemic actions against various forms of leukemia by several research groups throughout the 1980's. A similar quassinoid called glaucarubinone is found in Simaruba strong antileukemic and cytotoxic activities in other studies by various researchers. Another called glaucarubolone has demonstrated anti-leukemic, anti-tumorous, cytotoxic and antiviral properties in animals by several research groups in 1998.
Unpublished Data, National Cancer Institute. Anon: Nat Cancer Inst Central Files : - (1976) from the NAPRA report on Simaruba, University of Illinois.
Douros J, et.al., New natural products of interest under development at the National Cancer Institute. Cancer Chemother Pharmacol. 1978;1(2):91-100.
Polonsky J, 1978. The isolation and structure of 13,18-dehydroglaucarubinone, a new antineoplastic quassinoid from Simarouba amara. Experientia 34(9), 1122-1123
Klocke JA, et.al., 1985 Growth inhibitory, insecticidal and antifeedant effects of some antileukemic and cytotoxic quassinoids on two species of agricultural pests. Experientia. 1985 Mar 15;41(3):379-82.
Hall IH, Antitumor agents LIX: effects of quassinoids on protein synthesis of a number of murine tumors and normal cells. J Pharm Sci. 1983 Jun;72(6):626-30.
Considine RT, Structure-activity relationships for binding and inactivation of rabbit reticulocyte ribosomes by quassinoid antineoplastic agents. Eur J Biochem. 1983 Apr 15;132(1):157-63.
Liou YF, Antitumor agents XLVIII: Structure-activity relationships of quassinoids as in vitro protein synthesis inhibitors of P-388 lymphocytic leukemia tumor cell metabolism. J Pharm Sci. 1982 Apr;71(4):430-5.
Ghosh, PC, et.al. 1977. Antitumor plants. IV. Constituents of Simarouba versicolor. Lloydia 1977 Jul;40(4): 364-369
Wright CW, 1988. Use of microdilution to assess in vitro antiamoebic activities of Brucea javanica fruits, Simarouba amara stem, and a number of quassinoids. Antimicrob Agents Chemother 32(11), 1725-1729
Ohno N, et.al., Synthesis of cytotoxic fluorinated quassinoids. Bioorg Med Chem. 1997 Aug;5(8):1489-95.
Valeriote FA, et.al., 1998 Anticancer activity of glaucarubinone analogues. Oncol Res. 1998;10(4):201-8.
Morre DJ, et.al. 1998 Mode of action of the anticancer quassinoids--inhibition of the plasma membrane NADH oxidase. Life Sci. 1998;63(7):595-604.
Morre DJ, et.al., 1998 Effect of the quassinoids glaucarubolone and simalikalactone D on growth of cells permanently infected with feline and human immunodeficiency viruses and on viral infections. Life Sci. 1998;62(3):213-9
Anamu
Clinically, Anamu has demonstrated in vitro antileukemic and antitumorous properties in several studies. The plant contains Benzaldehyde as well as Coumarin, and both plant chemicals have been documented with antitumorous and/or anticancerous properties. Anamu has also been documented with in vivo and in vitro immunostimulant properties. In a 1993 study, a water extract demonstrated the ability to stimulate lymphocyte and Interleukin II production in mice. In the same year, another study with mice demonstrated that an Anamu extract increased Natural Killer Cell Activity by 100% and stimulated Interferon, Interleukin II and Interleukin 4 production. Newer research in 1999 and 2000 continues to substantiate Anamu's in vivo immunostimulant properties.
Jovicevic, L., In Vitro Antiproliferative Activity of Petiveria alliacea L. on Several Tumor Cell Lines. Pharmacol Res 27 1: 105-106 (1993)
Rossi, V., Antiproliferative Effects of Petiveria alliacea on Several Tumor Cell Lines. Pharmacol Res Suppl 22 2:434-.(1990)
Rossi, V., Effects of Petiveria alliacea L. on Cell Immunity. Pharmacol Res 27 1: 111-112 (1993)
Marini, S., Effects of Petiveria alliacea L. on Cytokine Production and Natural Killer Cell Activity Pharmacol Res 27 1:107-108 (1993)
Rocha AB, et.al., [Thin layer chromatographic analysis of coumarins and preliminary test for some active substance in the root of Petiveria alliacea L]. Rev Fac Farm Odontol Araraquara. 1969 Jan-Jun;3(1):65-72.
Quadros MR, et.al., Petiveria alliacea L. extract protects mice against Listeria monocytogenes infection--effects on bone marrow progenitor cells. Immunopharmacol Immunotoxicol. 1999 Feb;21(1):109-24. , Cytokine profile and natural killer cell activity in Listeria monocytogenes infected mice treated orally with Petiveria alliacea extract. Immunopharmacol Immunotoxicol. 2000 Aug;22(3):501-18.
Brazilian Peppertree
The bark, leaves and seeds of this plant have clinically demonstrated broad spectrum in vitro and in vivo antimicrobial activity against numerous bacteria, fungi and pathogens in several studies. In 1996 a U.S. patent was awarded for a essential oil preparation of Brazilian Peppertree as a topical bactericidal medicine used against Pseudomonas aeruginosa and Staphylococcus aureus for humans and animals and as an ear, nose and/or throat preparation against bacteria. In much earlier in vitro tests, it demonstrated antiviral actions against several plant viruses and was shown to be cytotoxic against 9kb cancer cells. The bark and leaves contain a phytochemical, gallic acid, which has been documented with anti-inflammatory, antimicrobial, antiviral and anticarcinomic properties.
Physicians' Desk Reference for Herbal Medicines, 2nd Ed., Medical Economics Company, Inc. Montvale, NJ, 2000
Perez, C., et.al., 1994. Inhibition of Pseudomonas Aerguinosa by Argentinean Medicinal Plants. Fitoterapia 65 2: 169-172
Bhakuni, D., et.al., 1976 Screening of Chilean Plants for Anticancer Activity. I. Lloydia 39 4: 225-243
Hartwell, J.L., 1971. Plants used againt cancer. A survey. Lloydia, p.30, 1967-1971.
Pozzo-Balbi, T., et.al., 1978. The Triterpenoid Acids of Schinus molle. Phytochemistry 17 : 2107-2110
Martinez MJ, Screening of some Cuban medicinal plants for antimicrobial activity. J Ethnopharmacol. 1996 Jul 5;52(3):171-4.
Dikshit A, 1986 Schinus molle: a new source of natural fungitoxicant. Appl Environ Microbiol 51(5), 1085-1088
Jain MK, Specific competitive inhibitor of secreted phospholipase A2 from berries of Schinus terebinthifolius. Phytochemistry. 1995 Jun;39(3):537-47.
L-Keltawi, N. et.al., 1980. Antimicrobial Activity of Some Egyptian Aromatic Plants.Herba Pol 26 4: 245-250
Gundidza, M., et.al., 1993. Antimicrobial Activity of Essential Oil from Schinus molle Linn. Central Africian J Med 39 11: 231-234
Ross, S., et.al., 1980. Antimicrobial Activity of Some Egyptian Aromatic Plants. Fitoterapia 51 : 201-205
Camano, R., Method for treating bacterial infections United States Patent 5,512,284 April 30, 1996
Camano, R., Essential oil composition with bactericide activity United States Patent 5,635,184 June 3, 1997
Carneiro Wanick M, [Antiinflammatory and wound healing action of Schinus aroeira Vell in patients with cervicitis and cervico-vaginitis].Rev Inst Antibiot (Recife). 1974 Dec;14(1-2):105-6.
Zaidi, S. et.al., 1970. Some Preliminary Studies of the Pharmacological Activities of Schinus molle. Pak J Sci Ind Res 13 : 53- (1970)
Cat's Claw
Mostly known for it's documented and patented alkaloids which stimulate the immune system. This has led to its use around the world as an adjunctive treatment for cancer and AIDS as well as other diseases which negatively impact the immunological system. In addition to it's immunostimulating activity, other anti-cancerous properties have been documented on the alkaloids as well as other constituents in Cat's Claw. Five of the oxindole alkaloids have been clinically documented with anti-leukemic properties, and various root and bark extracts have demonstrated anti-tumorous and antimutagenic properties. Stuppner, et.al. isolated a chemical called Uncarine F which demonstrated an inhibition of 50% in leukemic cell lines with no toxicity to healthy cells saying "This selectivity between leukemic and normal stem cells indicates that uncarine F may be considered as a possible drug for the treatment of patients with acute leukemia." Keplinger's reports on observatory trials with cancer patients taking Cat's Claw in conjunction with traditional cancer therapies like chemotherapy and radiation reported fewer side effects to the traditional therapies like hair loss, weight loss, nausea, secondary infections and skin problems.
U.S. Patents Filed
Rizzi, R. Mutagenic and Antimutagenic Activities of Uncaria tomentosa and its Extracts, Journal of Ethnopharmacology 38 (1993): 63-77.
Sheng Y, Induction of apoptosis and inhibition of proliferation in human tumor cells treated with extracts of Uncaria tomentosa. Anticancer Res. 1998 Sep-Oct;18(5A):3363-8.
Sheng Y, Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa. Phytomedicine. 2000 Apr;7(2):137-43.
Lemaire I, Stimulation of interleukin-1 and -6 production in alveolar macrophages by the neotropical liana, Uncaria tomentosa. J Ethnopharmacol. 1999 Feb;64(2):109-15.
Budzinski JW, et.al., An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine. 2000 Jul;7(4):273-82.
Sheng Y, Enhanced DNA repair, immune function and reduced toxicity of C-MED-100, a novel aqueous extract from Uncaria tomentosa. J Ethnopharmacol. 2000 Feb;69(2):115-26.
Keplinger K, Uncaria tomentosa (Willd.) DC.--ethnomedicinal use and new pharmacological, toxicological and botanical results. J Ethnopharmacol. 1999 Jan;64(1):23-34.
Wurm M, Pentacyclic oxindole alkaloids from Uncaria tomentosa induce human endothelial cells to release a lymphocyte-proliferation-regulating factor. Planta Med. 1998 Dec;64(8):701-4.
Krallendorn�, Uncaria tomentosa (Willd.) DC Root Extract.- Information for Physicians, and Dispensing Chemists, 3rd revised edition (Volders, Austria: Immodal Pharmaka GmbH, September 1995), 20 pp.
Keplinger, U.M, "Einfluss von Krallendorn extract auf Retrovirale Infektioned," Zurcher AIDS Kongress, Zurich, Switzerland, October 16-17, 1992, program & abstracts.
Stuppner, H. A Differential Sensitivity of Oxindole Alkaloids to Normal and Leukemic Cell Lines, Planta Medica 59, suppl. (1993): A583.
Peluso, G. "Effetto Antiproliferativo su Cellule Tumorali di Estrattie Metaboliti da Uncaria tomentosa. Studi in vitro Sulla Loro Azione DNA Polimerasi," 11 Congreso Italo-Peruano de Etnomedicina Andina, Lima, Peru, October 27-30, 1993: 21-22.
Rizzi, R. Bacterial Cytotoxicity, Mutagenicity and Antimutagenicity of Uncaria tomentosa and its Extracts.Antimutagenic Activity of Uncaria tomentosa in Humans. lst Colloque European D'Ethnopharmacologie, Metz, France, March 22-24, 1990
Vassourinha
Phytochemical screening of Vassourinha has shown that it is a source of novel flavonoids and terpene plant chemicals. Many of Vassourinha's tested biological activities are attributed to these phytochemicals; the main ones being Scopadulcic Acids A & B, Scopadiol, Scopadulciol, Scopadulin, Scoparic Acids A, B, and C. The antitumorous activity of scopadulcic acid B was demonstrated in a 1993 study. This same phytochemical and another called Scopadulin demonstrated antiviral properties in two prior studies, including against Herpes Simplex I in vivo in hamsters. Vassourinha is a good source of betulinic-acid, a phytochemical documented with anticarcinomic, antimelanomic, antiviral, and cytotoxic properties.
Kojima N, et.al., Geranylgeranyl diphosphate synthases from Scoparia dulcis and Croton sublyratus. cDNA cloning, functional expression, and conversion to a farnesyl diphosphate synthase. Chem Pharm Bull (Tokyo). 2000 Jul;48(7):1101-3.
Nishino H, 1993. Antitumor-promoting activity of scopadulcic acid B, isolated from the medicinal plant Scoparia dulcis L. Oncology 50(2), 100-103 (1993)
Hayashi, T., 1992 Scoparic Acid A, a Beta-glucuronidase Inhibitor from Scoparia dulcis. J Nat Prod55 12: 1748-1755
Pereira-Martins SR, In vitro and in vivo study of the clastogenicity of the flavone cirsitakaoside extracted from Scoparia dulcis L.(Scrophulariaceae). Teratog Carcinog Mutagen. 1998;18(6):293-302.
Hayashi T, A cytotoxic flavone from Scoparia dulcis L. Chem Pharm Bull (Tokyo). 1988 Dec;36(12):4849-51.
Hayashi, T., 1993. A New Chemotype of Scoparia dulcis. Phytochemistry 32 2: 349-352 (1993)
Kawasaki M, Structure of scoparic acid A, a new labdane-type diterpenoid from a Paraguayan crude drug "Typycha Kuratu". Chem Pharm Bull (Tokyo). 1987 Sep;35(9):3963-6.
Hayashi T, et.al., Antiviral agents of plant origin. III. Scopadulin, a novel tetracyclic diterpene from Scoparia dulcis L. Chem Pharm Bull (Tokyo). 1990 Apr;38(4):945-7.
Hayashi K, et.al., In vitro and in vivo antiviral activity of scopadulcic acid B from Scoparia dulcis, Scrophulariaceae, against herpes simplex virus type 1. Antiviral Res. 1988 Sep;9(6):345-54.
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